Its eastern terminus is at a signalized intersection with SR 51 in downtown Toledo.

Created in the late 1920s, this state route is located entirely within the city limits of Toledo.

It was originally routed along the portion of its present alignment between Secor Road at the southwest corner of the University of Toledo campus, at the time a state-maintained roadway that carried the designation of SR 183, and its current eastern terminus in downtown Toledo.

[7][8] Then, in 1939, SR 246 was extended again on the west side, this time utilizing Frankfort Road west of SR 295 to Fulton–Lucas Road, then south to County Road L (CR L), which SR 246 then used heading west across the entire width of Fulton County, and into Williams County.

[9][10] The 1937 and 1939 extensions of SR 246 were reversed by 1957, when the portions of the route west of US 20 in the western end of Toledo were removed from the state highway system.