Its northern terminus is at the Michigan State Line in Berkey.

The roadway continues into Michigan as county-maintained Silberhorn Highway.

[2] Designated in 1932, SR 295 was originally routed from its current eastern junction with SR 2 to its current northern terminus at the Michigan State Line in Berkey.

[3][4] One year later, the highway would be extended southward to SR 64 on the outskirts of Whitehouse.

[6][7] The southern terminus of SR 295 was at a T-intersection with US 24 approximately 5 miles (8.0 km) southwest of Waterville until August 2012 when US 24 was rerouted.