The highway runs from its southern terminus at a T-intersection with State Route 78 nearly 3.25 miles (5.23 km) northeast of Summerfield to its northern terminus at a Y-intersection with State Route 147 about 3.75 miles (6.04 km) northeast of Batesville on the Noble-Belmont County Line.

Along its path, State Route 379 passes through northwestern Monroe County and southwestern Belmont County.

This state highway is not included as a part of the National Highway System, a system of routes identified as being most important for the economy, mobility and defense of the nation.

Originally, the highway was a spur route, running along its current alignment from its present northern terminus at State Route 147 southwesterly to the northwestern Monroe County hamlet of Calais.

[2][3] Two years later, State Route 379 was extended to the southwest from Calais to end at its present southern terminus at State Route 78.