A part of the northern segment of the state highway runs through a small section of Wayne National Forest.

SR 378 begins at a four-way stop-controlled intersection in Union Township, within the unincorporated community of Getaway.

The two routes wind their way west for about 0.6 miles (0.97 km) before SR 378 breaks off of the concurrency to continue heading north along the creek's path.

Now heading in a more north-northwest direction for the remainder of the route, SR 378 is briefly within the boundaries of the Wayne National Forest.

[2][3] For its entire length, SR 378's surroundings consists of residential homes and small farms within the Symmes Creek valley.