Following Main Street north from there, the state highway crosses the Norfolk Southern Railway tracks, then passes some homes and then a small commercial district as it arrives at its junction with US 20.

Continuing north, SR 510 passes through a residential area, intersecting a few side streets along the way.

Departing Clyde heading due north, SR 510 enters into rural Sandusky County, specifically Green Creek Township, and passes amid wide-open farmland, with homes appearing every so often along the roadway.

Just north of there, SR 510 passes underneath the Ohio Turnpike, which carries Interstates 80 and 90.

North of there, continuing its way through farm country, SR 510 crosses CR 247 en route to arriving at its endpoint at US 6.