Its northern terminus is at another T-intersection, this time with SR 285 approximately 1.25 miles (2.01 km) south of the village of Senecaville.

A series of spur gravel roadways split off from the state highway in this stretch to provide connections to additional area residences.

With some patches of trees lining up along the roadway amid the open space, SR 566 passes the Township Road 120 intersection, then turns to the north.

The state highway then bends back to the northwest, is briefly brushed up against by woods on both sides.

and re-enters open farmland just before turning to the west, and arriving at its endpoint at a T-intersection with SR 285 south of the village of Senecaville.