Its eastern terminus is also at a T-intersection, this time at SR 260 approximately 7.25 miles (11.67 km) southwest of Graysville.

The entirety of the route passes amidst the Wayne National Forest.

The highway begins at a T-intersection with SR 145 in Monroe County's Elk Township.

SR 565 is a hilly, curvey route that trends in an easterly fashion through a predominantly wooded terrain, with open fields appearing on occasional, along with a few homes.

[4] This state route is not included as a portion of the National Highway System.