SR 627's western terminus is at a diamond interchange with the US 30/US 62 freeway in southeast Massillon.

Its eastern terminus is a diamond interchange with Interstate 77 at I-77 Exit 101 in southern Canton.

The entire routing of SR 627 is situated in the western portion of Stark County.

[5] In 1941, the northern terminus was moved to State Route 5 in Paris after the section between SR 82 and SR 5 was decommissioned to make way for the new Ravenna Army Ammunition Plant.

[7][8] The current SR 627 was established in 1987 along the routing between the US 30/US 62 and I-77 freeways that it utilizes to this day.