The highway runs for 4.3 miles (6.9 km) from a T-intersection with SR 313 approximately four miles (6.4 km) southwest of Salesville to its junction with SR 265 in Salesville.

This state route is also known as Kennonsburg Road for its entire length.

For its duration, SR 761 traverses hilly terrain that is composed of both forest and grassland.

Heading northeastward from its southern terminus, the state highway passes T-intersections with Noble County Road 33 and Eagon Hill Road, then bends to the north as it crosses the county line into Guernsey County's Millwood Township.

Turning to the northeast, SR 761 now curves its way through a heavily wooded stretch through the Sycamore Road intersection, then runs northerly briefly to where it meets New Gottengen Road.