The highway runs from its southern terminus at SR 13 in Somerset to its northern terminus at a T-intersection with SR 204 in Glenford.

SR 757 runs exclusively within northern Perry County.

[2] This state route came into existence in 1937, starting from SR 13 approximately 1.25 miles (2.01 km) northwest of Somerset, and utilizing Black Horse Road (County Road 27) up to where it meets the current SR 757, then following the current alignment of the highway from that point to its current northern terminus at SR 204 in Glenford.

[3][4] By 1957, the southern portion of SR 757 was re-aligned onto the routing that it follows today from the Black Horse Road intersection southeasterly to its intersection with SR 13 in Somerset.

[5][6] The entire route is in Perry County.