The highway runs from its southern terminus at a signalized intersection with U.S. Route 36 (US 36) in the eastern portion of the city of Mount Vernon to its northern terminus at SR 3 approximately 1.25 miles (2.01 km) north of the Mount Vernon city limits.

[5] The highway commences at a signalized intersection with US 36 at the eastern end of Mount Vernon.

Traveling north from there, while in within the city limits of Mount Vernon the highway passes through a primarily residential area, intersecting a few side streets along the way.

As SR 768 exits the city and enters Monroe Township, it abuts the eastern side of Hiawatha Golf Course.

The remainder of the highway passes amidst a blend of forest, open fields and houses prior to arriving at its endpoint at SR 3.