Its southern terminus is on the East Huntington Bridge with the unmarked West Virginia Route 106 south of Proctorville, and its northern terminus is at SR 141 nearly 7 miles (11 km) west of Gallipolis.

SR 775 begins on the East Huntington Bridge over the Ohio River at the West Virginia state line.

[6][7] The route heads north leaving the bridge and having an intersection with SR 7.

The road passes near commercial and residential properties, as a three-lane highway, two-lane northbound and one-lane southbound.

[6][7] The road has a T-intersection with SR 790, before turning towards the northwest and entering Gallia County.