State Route 141 (SR 141) is an east–west highway crossing through southeast Ohio, though it predominantly runs more north–south.

The route is very scenic as it travels through rural areas of Lawrence and Gallia Counties.

As you move further east, the road becomes somewhat flatter as it often parallels Symmes Creek.

Traveling the road from end to end, one will cross Symmes Creek five times and pass through several communities including Ironton, Hecla, Kitts Hill, Aid, Wilgus, Arabia, Waterloo, Cadmus, Gage, Centenary, and Gallipolis.

Because of the close proximity to Symmes Creek through the central portion of the route, the roadway is sometimes flooded in rainy periods.