From the southern terminus, the highway proceeds northeast through a series of sharp curves, providing access to Grand Lake Regional Airport, a general aviation facility.

It continues north to the former Teramiranda Airport, then crosses Echo Bay, leaving Monkey Island.

[1] The highway turns west as it approaches Miami, crossing over I-44 (the Will Rogers Turnpike) with no direct access.

As it enters Miami, it turns to the north, curving northeast to bridge the Neosho River, one of the two primary tributaries of Grand Lake.

[5] The highway's northern terminus was moved to Miami by 1972, extending it through rural Ottawa County and Fairland.