The highway heads east-southeast from this point, paralleling a rail line.

About three miles (4.8 km) away from the terminus, the highway breaks away from the railroad, heading on a more easterly course, bypassing Hayward to the north.

Just after entering Noble County, it runs along the north outskirts of Lucien.

The road then continues on a due east course before ending at US-77 west of Perry.

[5] By 1972, US-64 had been realigned, continuing due east from SH-74 rather than forming a concurrency with it.