It travels from south to north, paralleling Interstate 35 (I-35), connecting Texas to Kansas through the central part of the state.

North of Marietta, US-77 passes to the west of Lake Murray and its state park.

It then enters Carter County and Ardmore, where it is named Commerce Street through the city limits over a four-lane divided thoroughfare that includes frontage roads on each side from just south of SH-199 (West Broadway) to NW 12th Street much like a freeway or expressway, though all intersections on Commerce are at-grade.

North of Springer, US-77 reverts to a two-lane highway and enters the Arbuckle Mountains, providing access to Turner Falls and having some hairpin curves over a section of roadway paved and constructed in the 1920s using prison labor from the Oklahoma State Penitentiary in McAlester.

[2] I-35 and US-77 remain together until the Fort Smith Junction in downtown Oklahoma City, where it transfers onto Interstate 235.

It continues northbound to serve as the eastern terminus of State Highway 164 and turns eastward toward Perry.

After passing the north end of State Highway 86, it turns back northward and has a half-interchange with the Cimarron Turnpike.

[citation needed] Beginning in the mid-1990s, a massive Capital Improvement Project program was started to widen and reconstruct US-77 between Edmond on the Broadway Extension and the North 36th Street exit on I-235.

The project included widening to six or eight lanes, reconfiguring several interchanges, and installing a new BNSF Railway bridge over I-235.

State Highway 77D is a Y-shaped spur route through the Turner Falls area.

The main segment of the highway begins in Love County at SH-32, east of Marietta.

The eastern spur begins at Love County, near the south shores of Lake Murray.

It hugs the eastern shore of the lake while heading north, entering Carter County and reaching its northern terminus at US-70.