The highway runs from west to east across the southern part of the state, just north of the Red River.

SH-32 continues east from Courtney, crossing over Mud Creek, then passing through unincorporated Rubottom.

[4] Nine miles (14 km) east of Burneyville, SH-32 has an interchange with I-35 outside Marietta, the seat of Love County.

SH-32 continues east, following the curve of Lake Texoma's shoreline, passing through Lebanon.

As originally created, the route ran from SH-14 (present-day US-183) in Davidson to Waurika, passing through the towns of Grandfield, Devol, and Randlett and the counties of Tillman, Cotton, and Jefferson.

[2] As a result, SH-32 was discontiguous; one section stretched from Davidson to Ryan, while another began at a spur ending at the Jefferson–Love county line and continued east from there.

[7] The portion of SH-32 concurrent with US-81 between Waurika and Ryan, once necessary to connect to the now-decommissioned road, was removed on February 24, 1938.

[9] This brought the highway into Oklahoma much earlier, crossing the Red River much further west, in effect bypassing Wichita Falls, Texas.

At this time, SH-32 was at its zenith; stretching from Davidson to Kingston, the route covered a total of 152 miles (245 km) along present-day roads.

On September 6, 1966, after over twenty years of cosignage, SH-32 was truncated to its current western terminus in Ryan.