[7] Growing up, Kwame's parents expected him to become a physician, yet he gained interest in rap music from a very young age, when he wrote his own songs and performed at local shows since his days at the Anglican Senior High School in Kumasi.

[13][14] He also featured some renowned Ghanaian highlife and hiplife artists like Daddy Lumba, Kojo Antwi and Ofori Amponsah.

This resulted in one of the most memorable feuds the Ghanaian music scene has seen, with Obrafour challenging Okyeame Kwame to a rap battle on the streets which was never honored.

His stage name Okyeame chosen to reflect his lyrical fluidity means "linguist (of the royal court)" in his native Akan.

[19] His ability to also perform other music genres, including hip-hop, reggae, highlife, R&B, jazz, and others, has garnered him the title "Mr.

[27] Kwame runs his own record label, OK Music previously One Mic Entertainment and the defunct Firm Bridges Communications, co-founded with his wife,.

[28] The record label has overseen the production and management of artists such as Morris Devoice, Rex Omar, Bradez, Tattoo, Ben Brako, Kofi B, and other music talents in Ghana.

[38][39] In the same year, he was appointed ambassador for the Junior Boys Mentoring Conference, a youth-focused non-governmental initiative in Accra which seeks to equip young people with the necessary knowledge and skills that will enable them to tackle challenges as they come into contact with the outside world.

[45] Additionally, he was appointed as an ambassador by Water Aid for their Hygiene Behaviour Change Coalition (HBCC) as part of the COVID-19 Control initiative.

[37] In 2020, he teamed up with Jamaica dancehall act, Sizzla Kalonji on a song titled Come Home which urges all Africans in the diaspora to always remember to come back to their motherland.

[48] Okyeame Kwame has helped to discover native African talents by working as a judge on music reality shows in Ghana and has also acted in Ghanaian films like Ties That Bind, The Comforter and Amsterdam Diary.

[2] For his work in raising the funds to provide free screening for the Ghanaian urban and rural poor, Kwame has been appointed Hepatitis B Ambassador for the Ghana Health Service.

This commitment is then passed on to a successor, emphasizing a shift from merely planting trees to actively growing and safeguarding them as a means of protecting the climate.

[64] The People's Choice Practitioners Awards, organised by Media Men Ghana in April 2017 saw Okyeame receive the ‘Outstanding Health Ambassador’ honours presented to him by the Asantehene, his Majesty Otumfuo Osei Tutu II.

His selection as ambassador comes at the back of his recognition as a father with an enviable, amazing relationship with his children which had taken centre stage in the media over the years.

Owing to his willingness to contribute to making Africa a better place, Kwame was recently unveiled as the Climate Change Ambassador for the Ghana Dedicated Grant Mechanism (DGM),  one of the leading projects of Solidaridad, an international Civil Society Organization with 50 years of global experience in facilitating the development of socially responsible, ecologically sound and profitable supply chains.

His reasoning was rooted in the belief that animals, akin to humans, experience emotions and pain, leading him to resist contributing to the suffering of living beings by consuming them as food.

This announcement faced significant criticism from a segment of the Ghanaian population on social media, generating diverse opinions in response to Kwame's perspective.

He argues that plant-based sources offer sufficient protein, questioning the necessity of killing animals for meat consumption.

[76][77] During the controversial OccupyJulorbihouse protest organized by a group called Democracy Hub to address increased hardships and economic challenges, Kwame faced criticism on social media for not participating in the event.

This response followed a Twitter post by popular television host Naa Ashorkorr, who questioned who should be accountable for fixing the country.

However, a segment of Ghanaians, including politicians like Abraham Amaliba from the National Democratic Congress, criticized him for what they perceived as indecent exposure.

In response, Okyeame Kwame explained that the images were part of an advertisement for his boxer brand, humorously questioning whether he should have worn kente (traditional woven fabric) to cover up in the promotional photos.