He conducted many operas with Beniamino Gigli, with whom he also made famous recordings; Andrea Chénier, Tosca, Madama Butterfly.
In 1951 De Fabritiis conducted a series of performances in Mexico City with Maria Callas.
That same year he conducted the soundtrack of a filmed Tosca with Maria Caniglia (voicing the on-screen Franca Duval), and Franco Corelli.
He appeared widely in Europe, America and Japan, mostly conducting the standard Italian opera repertory.
He was admired for his italianate warmth of expression, and for his skills at balancing consideration for voices and instrumental details.