[2][3] Omega Mart features custom-made products available for purchase, such as Mammoth Chunks, Organic Moth Milk, Nut Free Salted Peanuts, Gender Fluid, and Plausible Deniability, one of the three brands of laundry detergent.

[6][7] The concept for Omega Mart first originated in 2009, when artists first created a DIY pop-up grocery store exhibit[3][8] which, according to the Las Vegas Review-Journal, was essentially "little more than cinder-block shelves with bottles of colored water".

[8] It was attempted again in 2012, as Meow Wolf's Chimera educational division worked with approximately one thousand students in Santa Fe, New Mexico's public schools to fill a mock grocery store with handmade fake products.

In January 2018, Meow Wolf announced they would launch their second permanent attraction (the first being Santa Fe's House of Eternal Return) in Las Vegas, which would be an anchor tenant of retail and entertainment complex AREA15.

A commercial for its opening, which featured Willie Nelson's face deepfaked onto another person's body,[17] was described by Shelby Stewart of the Houston Chronicle as giving Texans "an idea of what a grocery store ad on LSD might be like".