[4] The podcast is hosted by Mary Harris, who previously covered health for ABC News.

[5] WNYC chose Mary Harris as the host of the show because they were hoping to expand the demographic of their audience to include young women.

[8] The show was an attempt to create a health-oriented discussion that was more accessible to listeners.

[9] The show discusses topics such as laughter's effect on health, cancer, water pollution, transgender hormone therapy, and transgender health disparities.

[12][13] The show also discusses how some doctors struggle with addiction the same as their patients.