The second season of the American mystery comedy-drama television series Only Murders in the Building, often abbreviated as OMITB, premiered on June 28, 2022, on Hulu.

[4] In January 2022, Short announced that Shirley MacLaine and Amy Schumer were cast to guest star for the season.

[6] The episodes in the season were written by Hoffman, Noah Levine, Kristin Newman, Ben Smith, Valentina Garza, Rachel Burger, Matteo Borghese, Rob Turbovsky, Joshua Allen Griffith, Stephen Markley, Ben Philippe, Madeleine George and Kirker Butler.

[7] Principal photography for the season began on December 1, 2021, in the Upper West Side of New York City,[8] and continued through January 2022.

On July 15, 2022, "Angel in Flip-Flops", an original song that was played briefly in the fourth episode of the season, "Here's Looking at You", was released online.

The website's critics consensus states, "Only Murders in the Building gets a new lease on life with a knottier sophomore outing that retains the series' core charm and wit.