Oogonial stem cells

As the DTC undergoes mitosis, the cells move proximally along the organism and passing from the mitotic-proliferative region into the meiotic cycle.

During this cycle, the cells complete meiotic prophase before passing into the zone of oogenesis (or spermatogenesis, depending on the sex and age of the organism).

[10] In 2004, considerable evidence was provided for the existence of germline stem cells in adult mouse ovaries capable of generating oocytes to form new follicles.

However, in 2004, new research by Jonathan Tilly and colleagues came about to suggest that a new population of stem cells in female mammals does exist, which could possibly be used for personalized therapeutics.

This study challenged previously expected notions, as it contradicted the central dogma of oogenesis, and has thus led to a rapid increase in the amount of researching being conducted to suggest whether there does indeed exist oocyte stem cells in the mammalian ovary.

[23] Lineage tracing and other studies, following initial observations in Tilly's lab, have found no supporting evidence for oogonial stem cells.