In 1615 he married Ottavia Sacchetti (1590–1645), sister of Cardinal Giulio Cesare Sacchetti[3] who would later consecrate Orazio's brother Lelio.
The Sacchetti and Falconieri were already close; Orazio's father had made his fortune importing salt and as a result Orazio had business connections to Ottavia Sacchetti's father.
When Ottavia's first husband, Piero Alberti, died, marriage to Orazio was considered an excellent option for both families.
[4] Records indicate they had at least one son (Paolo Francesco Falconieri) who took ownership of the Villa Falconieri and took his father's titles.
Orazio later commissioned Borromini to renovate the church of San Giovanni dei Fiorentini to build a Falconieri family chapel for his burial and the burial of his brother Lelio Falconieri.