Osage Creek is a stream in Newton, Boone, and Carroll counties of northern Arkansas.
The stream headwaters arise in northern Newton County at 36°05′47″N 93°20′56″W / 36.09639°N 93.34889°W / 36.09639; -93.34889 at an elevation of 2,250 ft (690 m).
[1][2] The stream flows east then turns north just west of Compton roughly paralleling Arkansas Highway 43 to enter the southwest corner of Boone County.
The stream flows northwest past the communities of Delmar and Osage where it crosses under Arkansas Highway 68.
The stream crosses under Arkansas Highway 21 and Arkansas Highway 221 south of Berryville and enters the Kings River about five miles west of Berryville just south of US Route 62.