Osceola High School is an accredited comprehensive public high school located in Osceola, Arkansas, United States.

The school provides secondary education in grades 9 through 12 to more than 325 students in Osceola and nearby unincorporated communities.

The assumed course of study follows the Smart Core curriculum developed by the Arkansas Department of Education (ADE), which requires students complete at least 22 units prior to graduation.

[2] The Osceola High School mascot and athletic emblem is the Seminole (in honor of Seminole leader Osceola) with purple and gold serving as the school colors.

The Seminoles play within the 3A Region 3 Conference and participate in football, golf (boys/girls), basketball (boys/girls), competitive cheer, baseball, softball, and track (boys/girls).