The company is owned and operated by Norman Osborn who developed the Oz super soldier serum and the spiders who were behind the abilities of Peter Parker,[9] and later Miles Morales.

[10] After an incident in which Osborn injected himself with Oz serum and became the Green Goblin, a big portion of the main building was left in ruins, and numerous scientists died or transitioned to other companies like Roxxon in the case of Conrad Marcus.

[13] In Earth-6160, a world whose history was altered by the Maker, Oscorp is one of the largest companies of the North American Union, a regional power bloc which includes the former United States's territories after its central government dissolved in 1969.

As Stark/Stane's assets become a matter of question and political intrigue due to the fall of the Starks, Wilson Fisk, the new Shadow Governor of the New York territory and Kingpin of Manhattan, appoints Harry to help take care of them during a meeting.

Two weeks later, with the assistance of Otto Octavius, the Osborns covertly raid a hidden Stark location containing Iron Man armors, as well as a valuable data repository of files of information regarding suit designs, financial accounts, and the Council's operations.

Utilizing Stark technology, Octavius creates the Green Goblin suit as Harry decides to fight against the Kingpin and the Council's reign over New York and the rest of the world, in order to avenge his father's death.

In the films, Oscorp is portrayed as a powerful and corrupt scientific corporation headed by Norman Osborn and others like Rajit Ratha and Donald Menken, who uses the company's vast resources in various attempts to find a cure for his terminal disease.

Research stations were also set up throughout the city by Norman's son Harry Osborn to carry out his late mother Emily's wishes of eradicating pollution and cleaning the environment and are part of a side-quest in the first game.