Osyka is a town in Pike County, Mississippi, United States.

As of the 2020 United States Census, there were 381 people, 154 households, and 102 families residing in the town.

31.6% of all households were made up of individuals, and 19.2% had someone living alone who was 65 years of age or older.

The Town of Osyka is served by the South Pike School District.

[7] Pike County is in the district of Southwest Mississippi Community College.