Holmesville was named December 11, 1816 in honor of Major Andrew Hunter Holmes by commissioners who were appointed to select a spot for the seat of justice in the geographical center of the newly formed Pike County.

In 1857 the Illinois Central Railroad was built 9 mi (14 km) west bypassing Holmesville and the more populated area of the County.

In 1881, the newly built courthouse was destroyed by fire, and most records of Holmesville and Pike County were lost.

Holmesville became a great resort, and through the summer months was often crowded with people seeking rest and relief from the unhealthful atmosphere of New Orleans and the dangers of cholera and yellow fever which often prevailed there.

Its healthfulness, picturesque scenery, pure water, facilities for outdoor sports and quiet pleasures, made it a desirable place for a summer vacation.