Topisaw is an unincorporated community in Pike County, in the U.S. state of Mississippi.

[1] The community takes its name from Topisaw Creek, which flows near the site.

[2] Topisaw Creek is derived from the Otapasso tribe that lived in the area.

[1] A post office called Topisaw was established in 1880, and remained in operation until 1905.

This Pike County, Mississippi state location article is a stub.