Otothyropsis polyodon is a species of armored catfish found in the tributaries of the Rio Verde which is a tributary to the upper Rio Paraná basin in Mato Grosso do Sul, Brazil.

This species reaches a length of 3.7 cm (1.5 in).

[1] Poly means many; odon means tooth, referring to higher number of teeth compared to other species in this genus.

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