Otter Creek is a town in Levy County, Florida, United States.

The loss of a lumber mill that made cypress "flitches" for citrus crates and the discontinuation of two railroads which bisected the town led to a steady population decline.

[2] In 2007, the town council created a local historic district consisting of neighborhoods with "company town" residences that date from the 19th and early 20th century After the closure of the lumber mill, there has been very little business or commercial activity within Otter Creek.

By 2019, only two small businesses remained, an independently-owned convenience store (no gasoline) located at the intersection of Highways 19 and 24, and the Creekside Christian School, a private, primary school operating on the grounds of Otter Creek Baptist Church.

The Smith Store was operated by Ella Graham (deceased 1996), whose grandson once delivered groceries and dry goods to the town residents on a Shetland pony.

The Country Store, originally built and operated by Junior and Philene Williams, changed hands after their deaths, but permanently closed about 2000.

The climate in this area is characterized by hot, humid summers and generally mild winters.