Other notable family members include his son-in-law Hans-Constantin Paulssen (1892-1984), who was the first president of the BDA (Bundesvereinigung der Deutschen Arbeitgeberverbände) (Confederation of German Employers' Associations).
Otto studied medicine at Heidelberg, Strasbourg and Zurich, and beginning in 1877, worked under Ludwig Meyer (1827–1900) in the psychiatric clinic at the University of Göttingen.
[1] He was later associated with the pathological institute in Breslau, and in 1880 was appointed chief physician under Karl Friedrich Otto Westphal (1833–1890) in the psychiatric and neurological clinic at Charité Hospital in Berlin.
At Jena he worked with several young neurologists that included Theodor Ziehen (1862–1950), Oskar Vogt (1870–1959), Korbinian Brodmann (1868–1918), and Hans Berger (1873–1941).
[2][4] In his histopathological research he sought to explain similarities and differences between progressive paralysis and other types of organic brain disease.