From 1900 to 1901, Brodmann also worked in the Psychiatric Clinic at the University of Jena, with Ludwig Binswanger, and in the Municipal Mental Asylum in Frankfurt.

[citation needed] In 1909, Brodmann published his original research on cortical cytoarchitectonics in the monograph Vergleichende Lokalisationslehre der Großhirnrinde (Localisation in the cerebral cortex).

Finally, in 1918, he accepted an invitation from the University of Munich to direct the group of histology at Psychiatric Research Center.

Brodmann died in Munich rather suddenly of a generalized septic infection following pneumonia, at just under 50 years of age on 22 August 1918.

[3] Brodmann used a variety of criteria to map the human brain, including attention to both gross anatomical features and cortical micro-structures.