The Otto and Verdell Rutherford House is a historic building in Portland, Oregon, United States.

Otto Rutherford (1911–2000) and Verdell Burdine Rutherford (1913–2001) were leaders in the civil rights movement in Oregon, importantly as president (Otto, from 1952 to 1954) and secretary (Verdell, from the late 1940s through 1962) of the NAACP Portland branch.

Their house became a center of meeting, organization, planning, and publishing in support of the African American community's struggle for equal rights.

A notable success came with passage of the 1953 Oregon Public Accommodations Act, attributable in large measure to the Rutherfords' work.

It was located in the Albina district, the only place in Portland where the elder Rutherfords could purchase due to exclusionary redlining.