Ouse (/uːz/) is a small town in the Central Highlands local government area of Tasmania, Australia, on the Lyell Highway.

Ouse is the settlement where convicts James Goodwin and Thomas Connolly broke out of the South West Wilderness four weeks after their escape from Sarah Island.

[2] The town briefly made national headlines in August 2006 when the Ouse District Hospital, originally established as a Bush Nursing Centre and reconstituted in its present form in 1956,[3] was downgraded to a community health centre.

Ouse has an oceanic climate (Köppen: Cfb), with mild, dry summers and cool, somewhat damp winters.

Due to its inland location and being downwind of the Central Highlands, midsummer freezes have been recorded, while foehn winds occur (primarily in summer).