Oxford first received railroad service in the 1850s, when a line connecting the Chicago and Cincinnati rail networks was completed through the city.

Before the rise of the automobile, the station's passenger services brought students to and from Oxford's multiple colleges, including Miami University, and its freight services shipped local agricultural products to their markets.

A building known as the Junction House, located across the street from the depot, was built in 1860 and is closely associated with the railroad.

[2] The station was listed in the National Register of Historic Places on February 8, 1980, as the Oxford Railroad Depot and Junction House.

This article about a property in Butler County, Ohio on the National Register of Historic Places is a stub.