Subsequently, they also reached the round of 16 stage of the same competition, after playing two memorable matches against Lazio, including a 1–0 away win and a 3–3 home draw, before being eliminated by Spanish club Valencia.

Then, in the 2014–15 season, Ludogorets became the second Bulgarian team to reach the UEFA Champions League group stages (the first being Levski Sofia in 2006–07) after eliminating Steaua București 6–5 at penalties and the first one to score points in this phase following a 1–0 victory over FC Basel.

At their debut in the competition, Ludogorets won 2–0 at Eindhoven over PSV, obtaining their first European group stages victory.

On matchday 2, Ludogorets won 3–0 against Dinamo Zagreb, in a replay match from their previous Champions League season clash.

On matchday 3, Ludogorets again won 1–0 against Chornomorets Odesa, becoming the first Bulgarian team to begin their group stage participation in European tournaments with three consecutive wins without conceding any goal.

[6] Goalkeeper Vladislav Stoyanov was dismissed for a second yellow card in the last minute of extra time in the second leg, when Ludogorets had used all their substitutes.

[6] Ludogorets made their debut in the 2014–15 Champions League group phase on 16 September 2014, grabbing a 1-1 equalizer away against Liverpool in the 90th minute scored by Dani Abalo, but in an eventual 1-2 loss,[7] as the newly signed goalkeeper Milan Borjan then gave away a penalty with a foul on Javi Manquillo, which Steven Gerrard converted to give Liverpool the victory.

[9] In this game Cristiano Ronaldo took two penalties, with the first saved by the Ludogorets' goalkeeper Vladislav Stoyanov and the second converted into the goal for a 1-1 equalizer.