553319057ENSG00000120910ENSMUSG00000022092P48454P48455NM_001243974NM_001243975NM_005605NM_008915NM_001304991NM_001304992NM_001360229NP_001230903NP_001230904NP_005596NP_001291920NP_001291921NP_032941NP_001347158Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform (PP2BC) is an enzyme that in humans is encoded by the PPP3CC gene.

[5][6] Calmodulin-dependent protein phosphatase, calcineurin, is involved in a wide range of biologic activities, acting as a Ca(2+)-dependent modifier of phosphorylation status.

In testis, the motility of the sperm is thought to be controlled by cAMP-dependent phosphorylation and a unique form of calcineurin appears to be associated with the flagellum.

The calcineurin holoenzyme is composed of catalytic and regulatory subunits of 60 and 18 kD, respectively.

These genes have been identified in humans, mice, and rats, and are highly conserved between species (90 to 95% amino acid identity).