557319084ENSG00000108946ENSMUSG00000020612P10644Q9DBC7NM_212472NM_001369389NM_001369390NM_001362677NM_001373912NM_001373913NP_997637NP_001356318NP_001356319NP_001263218.1NP_001265362.1NP_002725.1NP_997636.1NP_997637.1NP_001349606NP_001360841NP_001360842cAMP-dependent protein kinase type I-alpha regulatory subunit is an enzyme that in humans is encoded by the PRKAR1A gene.

The inactive holoenzyme of PKA is a tetramer composed of two regulatory and two catalytic subunits.

[6] Functional null mutations in this gene cause Carney complex (CNC), an autosomal dominant multiple neoplasia syndrome.

[6] Mutation of PRKAR1A leads to the Carney complex, associating multiple endocrine tumors.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.