2WNT, 2Z7Q, 2Z7R, 2Z7S, 3RNY, 4H3P, 4NIF, 5CSJ, 5CSF, 5CSN, 5CSI619520111ENSG00000117676ENSG00000281877ENSMUSG00000003644Q15418P18653NM_001006665NM_002953NM_001330441NM_001285505NM_001285506NM_009097NM_001378880NP_001006666NP_001317370NP_002944NP_001272434.1Ribosomal protein S6 kinase alpha-1 is an enzyme that in humans is encoded by the RPS6KA1 gene.

[5] This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases.

This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway.

The activity of this protein has been implicated in controlling cell growth and differentiation.

Alternate transcriptional splice variants, encoding different isoforms, have been characterized.