Ribosomal s6 kinase

Cytosolic substrates of p90rsk include protein phosphatase 1; glycogen synthase kinase 3 (GSK3); L1 CAM, a neural cell adhesion molecule; Son of Sevenless, the Ras exchange factor; and Myt1, an inhibitor of cdc2.

[1] RSK phosphorylation of SOS1 (Son of Sevenless) at Serines 1134 and 1161 creates 14-3-3 docking site.

[2] p90rsk also regulates transcription factors including cAMP response element-binding protein (CREB); estrogen receptor-α (ERα); IκBα/NF-κB; and c-Fos.

Mutations in this gene have been associated with Coffin–Lowry syndrome, a disease characterised by severe psychomotor retardation and other developmental abnormalities.

Rsk was first identified in Xenopus laevis eggs by Erikson and Maller in 1985.

Some of the signalling events involving rsk.
Domain structure of rsk. Numbers refer to amino acid residues of p90 rsk-1 from rat. [ 6 ]