2IZX, 2KYG, 4ZP3557619087ENSG00000114302ENSMUSG00000032601P13861P12367NM_004157NM_001321982NM_001321983NM_001321989NM_008924NP_001308911NP_001308912NP_001308918NP_004148n/acAMP-dependent protein kinase type II-alpha regulatory subunit is an enzyme that in humans is encoded by the PRKAR2A gene.

[5] cAMP is a signaling molecule important for a variety of cellular functions.

The inactive holoenzyme of PKA is a tetramer composed of two regulatory and two catalytic subunits.

It may interact with various A-kinase anchoring proteins (AKAPs) and determine the subcellular localization of PKA.

This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER).