327615469ENSG00000126457ENSMUSG00000109324Q99873Q9JIF0NM_001207042NM_001536NM_198318NM_198319NM_001252476NM_001252477NM_019830NP_001193971NP_001527NP_938074NP_001239405NP_001239406NP_062804Protein arginine N-methyltransferase 1 is an enzyme that in humans is encoded by the PRMT1 gene.

[6] PRMT1 gene encodes for the protein arginine methyltransferase that functions as a histone methyltransferase specific for histone H4 in eukaryotic cells.

[6] Specifically altering histone H4 in eukaryotes gives it the ability to remodel chromatin acting as a post-translational modifier.

[7] While all PRMT enzymes catalyze the methylation of arginine residues in proteins, PRMT1 is unique in that is catalyzes the formation of asymmetric dimethylarginine as opposed to the PRMT2 that catalyzes the formation of symmetrically dimethylated arginine.

[8] Individual PRMT utilize S-adenosyl-L-methionine (SAM) as the methyl donor and catalyze methyl group transfer to the ω-nitrogen of an arginine residue.