[5][6][7] This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs).

The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA).

The hnRNP proteins have distinct nucleic acid binding properties.

The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs.

During neuronal differentiation, miR-124 reduces PTBP1 levels, leading to the accumulation of correctly spliced PTBP2 mRNA and a dramatic increase in PTBP2 protein.