The Palazzo Butera is a Baroque-style aristocratic palace located facing the Mediterranean in the ancient quarter of Kalsa of central Palermo, region of Sicily, Italy.

Some of the fresco decorations were pursued by Olivio Sozzi, Emanuele and Elia Interguglielmi, Gioacchino and Pietro Martorana, and the quadraturista Gaspare Fumagalli.

In 1773, Ercole Michele Branciforti e Pignatelli, prince of Pietraperzia, aligned with a local rebellion in Sicily and was jailed by the viceroy Caracciolo.

Upon the death of Stefania Branciforte, last princess of Butera, the titles were transferred to the Lanza family, princes of Trabia and Dukes of Camastra.

In 2016, the palace was purchased by the gallery owner Massimo Valsecchi and his wife Francesca, who have led a restoration of the structure for use as museum and cultural events.