Palazzo Datini is a late 14th-century palace in Prato, Tuscany, central Italy.

In 2015, the palace housed the offices of the Fondazione Casa Pia dei Ceppi, a charitable organization and a museum and archive.

Begun in 1383 as the residence of merchant Francesco Datini, it was subsequently decorated by artists such as Agnolo Gaddi and Niccolò di Pietro Gerini, both internally and externally, although the latter paintings are rather damaged.

In 1409 the palazzo was visited by Pope Alexander V and Louis II of Anjou, King of Naples.

[1] Filippo Lippi's Madonna del Ceppo was once located in the palace's garden.