Five halls of the piano nobile, with important frescoes and ceilings, are now the official reception rooms of the Equestrian Order of the Holy Sepulchre of Jerusalem.

The current name was added during the reign of Pope Alexander VII, who moved here the confessors working in Saint Peter's Basilica, known as penitenzieri.

The name of Domenico della Rovere is written on the windows of the first floor, while the coat of arms on the façade is that of Pope Clement XIV.

The interior has a court on two levels: a lower one with a portico featuring octagonal pillars and a pit, and an upper one with gardens.

In July 2023, archaeologists announced the discovery of the remains of the Theatre of Nero under the building's courtyard and gardens.