The Palazzo Diomede Carafa, also known as Palazzo Santangelo, or Santagelo Carafa, is a monumental Renaissance palace on Via San Biagio dei Librai #119–121 in central Naples, region of Campania, Italy.

It is said he engaged the architect Masuccio Secondo or Angelo Aniello Fiore in this work.

The palace passed from the son of Diomede, to the Counts of Maddaloni, and then the Carafa family of Columbrano.

[1] After the death of the Duchess Faustina Pignatelli, wife of Francesco Carafa di Columbrano, the palace fell into disrepair, until acquired in 1815 by Francesco Santangelo, a wealthy lawyer, and converted into a museum displaying archeologic collections.

[2] The palace has twelve faded niches depicting members of the Carafa lineage.