Ghino di Tacco, sea-captain and gentleman brigand, lived in the late 13th and early 14th centuries; Negro Ghini, Knight of Jerusalem and Crusader leader, died in Rhodes in 1330.
Around 1600 the Pope appointed the Ghini, who were already counts, to be marquesses of Romagna and patricians of Cesena and San Marino, and also gave them the fief of Roccabernarda.
The current palace was commissioned in the 1680s by the brothers Giacomo Francesco and Alessandro Bruno from the Cesena architect Pier Mattia Angeloni.
Monsignor Ghino gave the building the connotation of an ecclesiastical residence and donated it to the Cesena Jesuits, who, following his wishes, established their headquarters there from 1942 to 1962.
The courtyard facade is one of the most evocative in Cesena, with a splendid three-storey gallery, with white stone columns on the two lower levels, which affords a view of the front of the Malatestiana Library.